Opioid Receptor Interacting Proteins and the Control of Opioid Signaling

Author(s): Jennifer T. Lamberts, John R. Traynor

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 42 , 2013

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Opioid receptors are seven-transmembrane domain receptors that couple to intracellular signaling molecules by activating heterotrimeric G proteins. However, the receptor and G protein do not function in isolation but their activities are modulated by several accessory and scaffolding proteins. Examples include arrestins, kinases, and regulators of G protein signaling proteins. Accessory proteins contribute to the observed potency and efficacy of agonists, but also to the direction of signaling and the phenomenon of biased agonism. This review will present current knowledge of such proteins and how they may provide targets for future drug design.

Keywords: Opioid receptors, regulator of G protein signaling proteins, arrestins, G protein-coupled receptor kinases, protein kinase C, biased agonism, drug discovery.

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Article Details

Year: 2013
Page: [7333 - 7347]
Pages: 15
DOI: 10.2174/138161281942140105160625
Price: $65

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