Abstract
The influence of addition of dsDNA on the electrocatalytic effect of carbon matrices, e.g. synthetic monocrystalline diamond, fullerenes C60 and multi-walled carbon nanotubes was studied. Three neurotransmitters: dopamine, epinephrine and norepinephrine, which are known as biomarkers that play an important role in transporting and modulating nervous impulses in the synapse were chosen as model analytes. Cyclic voltammetry was used to determine the optimum working conditions with a phosphate buffer solution at a pH=4 with KNO3 as support electrolyte. Differential pulse voltammograms (DPVs) were employed to assess the electrolytic effect of dsDNA on carbon matrices under the optimized conditions, and the potential applications of the biosensors for pharmaceutical and biomedical analysis.
Keywords: dsDNA, sensors, carbon based matrices, neurotransmitters.
Current Pharmaceutical Analysis
Title:Influence of Physical Immobilization of dsDNA on Carbon Based Matrices of Electrochemical Sensors
Volume: 10 Issue: 1
Author(s): Livia Alexandra Gugoasa, Raluca-Ioana Stefan-van Staden, Anton Alexandru Ciucu and Jacobus Frederick van Staden
Affiliation:
Keywords: dsDNA, sensors, carbon based matrices, neurotransmitters.
Abstract: The influence of addition of dsDNA on the electrocatalytic effect of carbon matrices, e.g. synthetic monocrystalline diamond, fullerenes C60 and multi-walled carbon nanotubes was studied. Three neurotransmitters: dopamine, epinephrine and norepinephrine, which are known as biomarkers that play an important role in transporting and modulating nervous impulses in the synapse were chosen as model analytes. Cyclic voltammetry was used to determine the optimum working conditions with a phosphate buffer solution at a pH=4 with KNO3 as support electrolyte. Differential pulse voltammograms (DPVs) were employed to assess the electrolytic effect of dsDNA on carbon matrices under the optimized conditions, and the potential applications of the biosensors for pharmaceutical and biomedical analysis.
Export Options
About this article
Cite this article as:
Gugoasa Alexandra Livia, Staden Stefan-van Raluca-Ioana, Ciucu Alexandru Anton and Staden Frederick van Jacobus, Influence of Physical Immobilization of dsDNA on Carbon Based Matrices of Electrochemical Sensors, Current Pharmaceutical Analysis 2014; 10 (1) . https://dx.doi.org/10.2174/157341291001140102104740
DOI https://dx.doi.org/10.2174/157341291001140102104740 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Chinese Medicine in Inhalation Therapy: A Review of Clinical Application and Formulation Development
Current Pharmaceutical Design Possible Underestimation by Sports Medicine of the Effects of Early Physical Exercise Practice on the Prevention of Diseases in Adulthood
Current Diabetes Reviews Dietary Antioxidants as Potential Pharmacological Agents for Ischemic Stroke
Current Medicinal Chemistry Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
Current Genomics The Mechanism of Calcitriol in Cancer Prevention and Treatment
Current Medicinal Chemistry Retracted: Junk Food Consumption, Perceptions and Associated Factors among the Private School Children
Current Nutrition & Food Science Female Infertility and Cardiovascular Risk - A Hype or an Underestimated Reality?
Current Pharmaceutical Design The Long Run: Neuroprotective Effects of Physical Exercise on Adult Neurogenesis from Youth to Old Age
Current Neuropharmacology Anesthesia and Postoperative Cognitive Dysfunction (POCD)
Central Nervous System Agents in Medicinal Chemistry Cellular Cardiomyoplasty – Challenges of a New Era
Current Tissue Engineering (Discontinued) Interrelationships with Metabolic Syndrome, Obesity and Cardiovascular Risk
Current Vascular Pharmacology Steerable Sheath Technology in the Ablation of Atrial Fibrillation
Recent Patents on Cardiovascular Drug Discovery MicroRNAs: Important Epigenetic Regulators in Osteoarthritis
Current Genomics Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting
Current Medicinal Chemistry Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials
Current Pharmaceutical Biotechnology The Contribution of Mannose Binding Lectin to Reperfusion Injury after Ischemic Stroke
Current Neurovascular Research Long-term Success and Follow-up After Atrial Fibrillation Ablation
Current Cardiology Reviews Respiratory Syncytial Virus (RSV) Prevention and Treatment: Past, Present, and Future
Cardiovascular & Hematological Agents in Medicinal Chemistry Clinical Aspects of Melatonin in the Acute Coronary Syndrome
Current Vascular Pharmacology Anti-Inflammatory and Pro-Resolving Effects of N-3 PUFA in Cancers: Structures and Mechanisms
Current Topics in Medicinal Chemistry