A series of 30 novel thiazolidine-2,4-diones (3a-o, 4a-o) have been synthesized and evaluated for their antibacterial
and antifungal activities against pathogenic microorganisms Gram-positive bacteria: Staphylococcus aureus, Bacillus
subtilis, Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia,
and fungal strains Candida albicans, Aspergillus niger using two fold serial dilution method.. In the present study thiazolidine-
2,4-dione derivatives has been substituted with electronegative groups at the 3rd and the 5th position. Some of the
compounds have shown promising antimicrobial activity.
Keywords: Antibacterials, antifungal, MIC, synthesis, thiazolidine-2, 4-dione, two fold serial dilution method.
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