Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones

Author(s): Radhe S. Bahare, Swastika Ganguly.

Journal Name: Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry

Volume 12 , Issue 1 , 2014

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A series of 30 novel thiazolidine-2,4-diones (3a-o, 4a-o) have been synthesized and evaluated for their antibacterial and antifungal activities against pathogenic microorganisms Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger using two fold serial dilution method.. In the present study thiazolidine- 2,4-dione derivatives has been substituted with electronegative groups at the 3rd and the 5th position. Some of the compounds have shown promising antimicrobial activity.

Keywords: Antibacterials, antifungal, MIC, synthesis, thiazolidine-2, 4-dione, two fold serial dilution method.

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Article Details

Year: 2014
Page: [112 - 119]
Pages: 8
DOI: 10.2174/221135251201140102003059

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PDF: 57