Protective Effect of CCR5 Delta-32 Allele Against HIV-1 in Mexican Women

Author(s): JesUs A. Estrada-Aguirre, Silvestre G. Cazarez-Salazar, Luis A. Ochoa-Ramirez, Selene de J. Acosta-Cota, Roman Zamora-Gomez, Guilermi M. Najar-Reyes, Perla Villarreal-Escamilla, Ignacio Osuna-Ramirez, Sylvia P. Diaz-Camacho, Jorge G. Sanchez-Zazueta, Juan J. Rios-Tostado, Jesus S. Velarde-Felix

Journal Name: Current HIV Research

Volume 11 , Issue 6 , 2013

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Abstract:

C-C chemokine receptor type 5 (CCR5) is known for its role as a co-receptor for HIV-1 infection. Some individuals possess a 32 bp deletion, known as Delta-32 allele which has been reported to confer resistance to HIV-1 infection. In order to estimate the distribution of Delta-32 allele of CCR5 gene, 1034 mestizo individuals from the Northwest of Mexico, including 385 HIV-1-infected individuals, 472 healthy controls and 177 uninfected female sex workers; were examined by allele-specific PCR. There was no statistically significant difference in the frequency of Delta-32 allele between HIV-1 positive and healthy individuals (OR= 1.1, p= 0.6). However, we found a significantly reduced prevalence of CCR5 Delta-32 heterozygous genotype in female patients (OR= 0.084, 95% CI= 0.011 - 0.630, p= 0.002), as well as in allele frequency, compared to male patients. Furthermore, we observed an inverse relationship between allele frequency and the risk of HIV-1 transmission and AIDS progression among female healthy controls, sex workers and HIV-1 infected groups. Our findings support previous data showing Delta-32 as a genetic protective factor against HIV-1 infection in Mexican women, as well as in women from other populations.

Keywords: AIDS, CCR5, delta-32, genetic marker, HIV-1, population genetics.

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Article Details

VOLUME: 11
ISSUE: 6
Year: 2013
Page: [506 - 510]
Pages: 5
DOI: 10.2174/1570162X11666140101120225
Price: $65

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