Abstract
A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.
Keywords: Annulation, piperidine, recyclable, tandem, Tungstophosphoric acid.
Combinatorial Chemistry & High Throughput Screening
Title:H3PW12O40-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines
Volume: 17 Issue: 6
Author(s): Samad Khaksar, Seyed Meysam Baghbanian and Nastaran Barsan
Affiliation:
Keywords: Annulation, piperidine, recyclable, tandem, Tungstophosphoric acid.
Abstract: A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.
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Cite this article as:
Khaksar Samad, Baghbanian Meysam Seyed and Barsan Nastaran, H3PW12O40-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines, Combinatorial Chemistry & High Throughput Screening 2014; 17 (6) . https://dx.doi.org/10.2174/1386207316666131229132950
DOI https://dx.doi.org/10.2174/1386207316666131229132950 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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