H3PW12O40-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines

Author(s): Samad Khaksar, Seyed Meysam Baghbanian, Nastaran Barsan

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 17 , Issue 6 , 2014

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Abstract:

A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.

Keywords: Annulation, piperidine, recyclable, tandem, Tungstophosphoric acid.

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Article Details

VOLUME: 17
ISSUE: 6
Year: 2014
Published on: 26 June, 2014
Page: [503 - 508]
Pages: 6
DOI: 10.2174/1386207316666131229132950
Price: $65

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