Title:Potent Phosphatidylinositol 3-Kinase Inhibitors and Their Biology
VOLUME: 11 ISSUE: 2
Author(s):Mukesh Chandra Joshi, Krishan Kumar and Vikrant Kumar
Affiliation:Department of Chemistry, Motilal Nehru College, University of Delhi, Delhi-110021, India.
Keywords:Clinical trial, glioblastoma cell lines, leukemia and lymphoma cell lines, phosphoinositide 3-kinase, proliferation,
tumor inhibitors.
Abstract:The Phosphoinositide 3-kinase (PI3k) is an important regulator of intracellular signalling pathways, like cell
proliferation, migration, survival, and angiogenesis upon activation by growth factor or receptors. The PI3k’s pathway is
frequently up-regulated in human cancers, thus inhibition of PI3k’s is a promising approach for cancer therapy. Many potent
PI3k’s inhibitors have been reported so far and few of them are in clinical trial like GDC-0941, BGT-226, AZD-6482
and others are natural products etc.
