Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Calcium Ion – The Key Player in Cerebral Ischemia

Author(s): V.S. Suvanish Kumar, A. Gopalakrishnan, M. Naziroglu and G.K. Rajanikant

Volume 21, Issue 18, 2014

Page: [2065 - 2075] Pages: 11

DOI: 10.2174/0929867321666131228204246

Price: $65

Abstract

Role of calcium ion (Ca2+) in the functioning of neurons from their naïve state to mature state is of vital importance. It controls functions such as neuronal functioning, neuronal ATP production, central nervous system migration and many others. Failure in Ca2+ homeostasis mechanisms and the resulting cellular Ca2+ ion load initiates a cascade of reactions involving various cytosolic enzymes and proteins. This total mechanism leads to the neuronal death. The ability of neurons to resist such death mechanisms fails as a result of extensive cell death signaling cascade reactions and later brings brain damage. The role of neuronal endoplasmic reticulum and protein channels like CaVs, TRP channels, and NMDAR as the mediators of cell damage and death has been evaluated in the studies related to cerebral ischemia. Here, we portray Ca2+ ion as one of the role players in neuronal death and cerebral damage following ischemia. The role of Ca2+ in neuronal functioning, its regulatory mechanisms and the failure of homeostatic mechanisms are discussed in detail.

Keywords: Ca2+ channels, Ca2+ ion, ischemia, neuronal damage, neuroprotection.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy