Title:PET Imaging to Monitor Cancer Therapy
VOLUME: 14 ISSUE: 7
Author(s):Gaurav Malviya and Tapan K. Nayak
Affiliation:Pharma Research and Early Development, F Hoffmann-La Roche, Grenzacherstrasse 124, Basel-4070, Switzerland.
Keywords:Biomarker, Cancer, Molecular imaging, Monitoring response to therapy, Positron Emission Tomography.
Abstract:Improved knowledge and understanding of key aspects of cancer has led to the development of novel cancer
therapeutics acting through complex pathways and mode of actions. The success of these novel cancer therapeutics is
often difficult to predict using standard response criteria based on anatomic changes. Monitoring response to cancer
therapy at molecular level using Positron Emission Tomography (PET) has gained popularity in recent years. PET allows
longitudinal assessment of specific biological processes rather than just changes in anatomic changes in tumor size. In this
review, we provide an overview on application for PET imaging to monitor cancer therapy with emphases on PET of
tumor metabolism, cell proliferation, angiogenesis, hypoxia and receptor dynamics.
