Endothelial Cell Targeted Molecular Imaging in Tumor Angiogenesis: Strategies and Current Status

Author(s): Ye Xu, Yun Zeng, Yanhong Liu, Gang Liu, Hua Ai

Journal Name: Current Pharmaceutical Biotechnology

Volume 14 , Issue 7 , 2013

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Abstract:

Angiogenesis plays crucial roles in tumor growth, progression and metastasis. Non-invasive in vivo imaging of tumor neovasculature is a fundamental prerequisite for effective therapeutic intervention, particularly anti-angiogenic treatment regimens. Emerging molecular imaging techniques now allow recognition of cellular/molecular processes before gross pathological changes, leading to better understanding of fundamental biological processes of tumor angiogenesis. In this review, we will summarize recent progresses on molecular imaging of attractive biochemical epitopes in tumor angiogenesis, especially the endothelial cell targets-based imaging probes.

Keywords: Angiogenesis, Contrast agent, Molecular imaging, Tumor, Vascular imaging.

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Article Details

VOLUME: 14
ISSUE: 7
Year: 2013
Page: [644 - 657]
Pages: 14
DOI: 10.2174/1389201014666131224154028
Price: $65

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