Abstract
A series of new α-aryl propionic acid derivatives had been synthesized through different synthetic routes from the readily available 2-fluoronitrobenzene as key starter. The synthesized compounds were screened for their antiinflammatory activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good antiinflammatory activity. The present series with some modification may serve as important core for the development of new anti-inflammatory agents.
Keywords: Azoles, α-Aryl propionic acid, non-steroidal anti-inflammatory drugs, rat paw edema, suzuki cross-coupling reaction.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents
Volume: 13 Issue: 2
Author(s): Laxmikant H. Nitlikar, Jaiprakash N. Sangshetti and Devanand B. Shinde
Affiliation:
Keywords: Azoles, α-Aryl propionic acid, non-steroidal anti-inflammatory drugs, rat paw edema, suzuki cross-coupling reaction.
Abstract: A series of new α-aryl propionic acid derivatives had been synthesized through different synthetic routes from the readily available 2-fluoronitrobenzene as key starter. The synthesized compounds were screened for their antiinflammatory activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good antiinflammatory activity. The present series with some modification may serve as important core for the development of new anti-inflammatory agents.
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Nitlikar H. Laxmikant, Sangshetti N. Jaiprakash and Shinde B. Devanand, Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2014; 13 (2) . https://dx.doi.org/10.2174/1871523012666131224110834
DOI https://dx.doi.org/10.2174/1871523012666131224110834 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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