Generic placeholder image

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents

Author(s): Laxmikant H. Nitlikar, Jaiprakash N. Sangshetti and Devanand B. Shinde

Volume 13, Issue 2, 2014

Page: [128 - 138] Pages: 11

DOI: 10.2174/1871523012666131224110834

Price: $65

Abstract

A series of new α-aryl propionic acid derivatives had been synthesized through different synthetic routes from the readily available 2-fluoronitrobenzene as key starter. The synthesized compounds were screened for their antiinflammatory activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good antiinflammatory activity. The present series with some modification may serve as important core for the development of new anti-inflammatory agents.

Keywords: Azoles, α-Aryl propionic acid, non-steroidal anti-inflammatory drugs, rat paw edema, suzuki cross-coupling reaction.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy