Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents

Author(s): Laxmikant H. Nitlikar, Jaiprakash N. Sangshetti, Devanand B. Shinde

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Volume 13 , Issue 2 , 2014

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Graphical Abstract:


A series of new α-aryl propionic acid derivatives had been synthesized through different synthetic routes from the readily available 2-fluoronitrobenzene as key starter. The synthesized compounds were screened for their antiinflammatory activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good antiinflammatory activity. The present series with some modification may serve as important core for the development of new anti-inflammatory agents.

Keywords: Azoles, α-Aryl propionic acid, non-steroidal anti-inflammatory drugs, rat paw edema, suzuki cross-coupling reaction.

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Article Details

Year: 2014
Published on: 17 September, 2014
Page: [128 - 138]
Pages: 11
DOI: 10.2174/1871523012666131224110834
Price: $65

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