Cyclodextrin/Dendrimer Conjugates as DNA and Oligonucleotide Carriers

Author(s): Hidetoshi Arima, Keiichi Motoyama, Taishi Higashi

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 4 , 2014

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Recently, various cyclodextrin (CyD)-grafted polymers and supramolecules have been developed as gene and oligonucleotide carriers. We have demonstrated that among the various polyamidoamine starburstTM dendrimers (dendrimers) conjugates with CyDs (CDEs), the dendrimer (G2 or G3) conjugate with α-CyD showed high gene and oligonucleotide transfer activity with negligible cytotoxicity. In addition, to develop tissue- or cell-specific gene transfer carriers, we also prepared α-CDEs modified with functional molecules, such as mannose, fucose, galactose, lactose, polyethylene glycol (PEG) and folate-PEG. Moreover, polypseudorotaxane-appended α-CDEs were developed as sustained release systems for DNA and siRNA. Interestingly, glucronylglucosyl-β-CyD conjugates with dendrimer (G2) (GUG-β-CDE (G2)) showed high gene transfer activity compared to α-CDE (G2) and β-CDE (G2). In this review, we focus on the potential use of various CDEs as DNA and oligonucleotide transfer carriers.

Keywords: Cyclodextrin, polyamidoamine dendrimer, gene, oligonucleotide, sugars, folic acid, polypseudorotaxane.

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Article Details

Year: 2014
Published on: 12 February, 2014
Page: [465 - 477]
Pages: 13
DOI: 10.2174/1568026613666131219123610
Price: $65

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