Indocyanine Green: Photosensitizer or Chromophore? Still a Debate

Author(s): Camille Giraudeau, Albert Moussaron, Aurelie Stallivieri, Serge Mordon, Celine Frochot

Journal Name: Current Medicinal Chemistry

Volume 21 , Issue 16 , 2014

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Abstract:

Indocyanine green (ICG) is a water-soluble anionic tricarbocyanine dye developed during the Second World War that was first approved for clinical use in humans in 1956. The main features of ICG that make it suitable for bioimaging applications are its near infrared absorption and its fluorescence. Although ICG is mainly used for its fluorescence emission properties, it has also been hypothesized that it can serve as a photosensitizer for photodynamic therapy applications, eliciting cytotoxic effects both in vitro and in vivo when used in combination with light at wavelengths in the region of 800-830 nm. Moreover, ICG can be used for hyperthermia of enhanced-photocoagulation of blood vessels treatment. In this paper we have gathered all the available data concerning the use of ICG for different treatments.

Keywords: Cytotoxic effects, fluorescence, hyperthermia, indocyanine Green (ICG), photodynamic therapy (PDT), selective photocoagulation, site-specific therapy.

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Article Details

VOLUME: 21
ISSUE: 16
Year: 2014
Page: [1871 - 1897]
Pages: 27
DOI: 10.2174/0929867321666131218095802
Price: $65

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