One-Pot Multi-Component Route to Propargylamines Using Zinc Oxide Under Solvent-Free Conditions

Author(s): Mona Hosseini-Sarvari, Fatemeh Moeini

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 17 , Issue 5 , 2014

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In this paper, commercially available ZnO was found to be a highly effective catalyst for three-component coupling reactions of alkynes, aldehydes/or ketone and amines (A3-coupling) via C-H activation. The reactions could be applied to both aromatic and aliphatic aldehydes. Nearly quantitative yields of the desired products were obtained in most cases. No co-catalyst or activator is required, and water is the only by-product in the reactions. Heterogeneous nature of the catalyst made it reusable for further chemical reactions.

Keywords: Amine, propargylamine, three-component reactions, ZnO.

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Article Details

Year: 2014
Published on: 16 June, 2014
Page: [439 - 449]
Pages: 11
DOI: 10.2174/1386207316666131217104925
Price: $65

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