Abstract
Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity. Successful cancer treatment would need to eliminate CSCs. The CSCs can be identified and isolated by both CSC-specific cell surface marker expression and functional assay, such as floating spheres, and aldehyde dehydrogenase (ALDH) activity assay. However, lack of universal expression of surface markers limits their usage to identify CSCs. Here, we give a brief overview of the current known surface markers of CSCs and associated tumor types. Finally, the possible reasons for contradiction are discussed in these surface markers. In this review, I not only provide an overview of the current known surface markers but also highlight the importance of achieving maximal accuracy of a new marker.
Keywords: Aldehyde dehydrogenase, cancer stem cells, differentiation, surface marker, self-renew.
Current Stem Cell Research & Therapy
Title:Surface Markers of Cancer Stem Cells in Solid Tumors
Volume: 9 Issue: 2
Author(s): Pu Xia
Affiliation:
Keywords: Aldehyde dehydrogenase, cancer stem cells, differentiation, surface marker, self-renew.
Abstract: Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity. Successful cancer treatment would need to eliminate CSCs. The CSCs can be identified and isolated by both CSC-specific cell surface marker expression and functional assay, such as floating spheres, and aldehyde dehydrogenase (ALDH) activity assay. However, lack of universal expression of surface markers limits their usage to identify CSCs. Here, we give a brief overview of the current known surface markers of CSCs and associated tumor types. Finally, the possible reasons for contradiction are discussed in these surface markers. In this review, I not only provide an overview of the current known surface markers but also highlight the importance of achieving maximal accuracy of a new marker.
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Cite this article as:
Xia Pu, Surface Markers of Cancer Stem Cells in Solid Tumors, Current Stem Cell Research & Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574888X09666131217003709
DOI https://dx.doi.org/10.2174/1574888X09666131217003709 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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