Introduction: alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen
atoms. In particular berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids
with anti-lipogenic and hypoglycemic effects. On the other hand, mate plant has reported to have high antioxidant potential,
including an inhibitory ability against plasma and LDL oxidation. Areas covered: Most of the studies reported in literature
about alkaloids are pre-clinical trials, and we have already discussed them in a previous review we conducted. This
time we want to focus our attention on clinical studies about berberine, and mate plant, so the aim of this review is to
evaluate berberine and mate plant efficacy and safety in humans. Conclusion: Berberine is a potent oral hypoglycemic
agent with a good effect on lipid metabolism. It is safe and the cost of treatment is very low. Also mate plant seems to
have antioxidant and hypolipidemic actions, even if further studies are necessary.
Keywords: Alkaloids, berberine, lipid profile, mate plant, type 2 diabetes mellitus.
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