The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed
at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this area has
been achieved with nanodevices possessing multiple properties and assembled with new, biodegradable, synthetic polymers
and polysaccharides. Different synthetic routes and multiple strategies, such as multilayer systems and stimuliresponsive
polymers, have been developed to attain high efficiencies. This review covers the most important, promising
and successful approaches to improve siRNA delivery. It is a concise report on multiple strategies employed, including
cell-specific delivery coupling ligands or antibodies with nanodevices to improve siRNA efficiency and specificity.
Keywords: Gene therapy, nanoparticles, multifunctional, polycations, stimuli-responsive polymers, siRNA delivery.
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