A number of patents on PET imaging have been reviewed with the intention of highlighting those that have
applications to bone imaging for skeletal surgery applications. The factors influencing radionuclide uptake into skeletal
structure are introduced as well as the basics of PET imaging and its effect on skeletal image appearance. The patents are
separated into three groups, PET imaging and detection, Radiopharmaceuticals, and labeling methods, and reviewed based
on practical applicability to skeletal imaging and potential to use the image for guiding skeletal surgery. The patents that
have the most potential for use in guiding skeletal surgery are those that involve the use of a radiopharmaceutical that
absorbs into the bone in areas of increased metabolic activity to highlight focused bone disease, abnormalities or growth.
The analysis suggests that PET imaging with FDG and NaF have high sensitivity and specificity and has the potential for
guiding surgery applications.