Surgical Inflammation

Surgical Inflammation

Indexed in: EBSCO, Book Citation Index, Science Edition.

This monograph offers the reader an integrated point-of-view about the inflammatory response related to injury, infections and tumors. This integration is based on the hypothesis that the multiple ...
[view complete introduction]

US $
30

*(Excluding Mailing and Handling)



Experimental Models of Surgical Inflammation

Pp. 309-343 (35)

Maria-Angeles Aller, Natalia de las Heras, Natalia Arias, Isabel Prieto, Laureano Lorente, Maria-Paz Nava, Luis Santamaria, Jorge-Luis Arias, Vicente Lahera and Jaime Arias

Abstract

Prehepatic portal hypertension induces a splanchnic low-grade inflammatory response that could switch to high-grade inflammation with the development of severe and life-threatening complications when associated with chronic liver disease. The extraembryonic origin of the portal system may determine the regression to an extraembryonic phenotype i.e., vitellogenic and amniotic, during the evolution of both types of portal hypertension. Thus prehepatic portal hypertension, or compensated hypertension by portal vein ligation in the rat, is associated with molecular mechanisms related to vitellogenesis, where hepatic steatosis and splanchnic angiogenesis stand out. In turn, extrahepatic cholestasis in the rat induces intrahepatic portal hypertension, or decompensated hypertension, with ascites and hepatorenal syndrome. The splanchnic interstitium, the mesenteric lymphatic system, and the peritoneal mesothelium seem to create an inflammatory pathway that could have a key pathophysiological relevance in the production of ascites. The hypothetical comparison between the ascitic and the amniotic fluid also allows for translational investigation. The induced regression of the splanchnic system to extraembryonic functions by portal hypertension highlights the great relevance of the extraembryonic structures even during post-natal life.

Keywords:

Portal hypertension, microsurgery, extrahepatic cholestasis, ascites, mini-brain, high grade inflammation, fetal development, amniotic fluid, lymph flow, hepatic steatosis, mast cell, splanchnic system.

Affiliation:

Department of Surgery, School of Medicine, Complutense University, Ramón y Cajal Square, 28040 MADRID, Spain.