Surgical Inflammation: From Molecule to Clinic
Pp. 18-50 (33)
Jose-Ignacio Arias, María-Angeles Aller, Gregorio Rodríguez-Boto, Manuel Giner and Jaime Arias
Tetrapyrrole molecules are distributed in virtually all living organisms on
Earth. In mammals, tetrapyrrole end products are closely linked to oxygen metabolism.
Since increasingly complex trophic functional systems for using oxygen are considered
in the post-traumatic inflammatory response, it can be suggested that tetrapyrrole
molecules and, particularly their derived pigments, play a key role in modulating
inflammation. In this way, the diverse colorfulness that the inflammatory response
triggers during its evolution would reflect the major pathophysiological importance of
these pigments in each one of its phases. Hence, the need of exploiting this color
resource could be considered for both the diagnosis and treatment of the inflammation.
Post-traumatic inflammatory response, oxygen metabolism,
tetrapyrroles, edema, necrosis, ischemia-reperfusion, hypoxia, cyanosis,
ecchymosis, hemoglobin, pus, suppuration, scar.
Cátedra de Cirugía, Facultad de Medicina, Universidad Complutense, Pza. de Ramón y Cajal s.n., 28040 MADRID, Spain.