Surgical Inflammation

Surgical Inflammation

Indexed in: EBSCO, Book Citation Index, Science Edition.

This monograph offers the reader an integrated point-of-view about the inflammatory response related to injury, infections and tumors. This integration is based on the hypothesis that the multiple ...
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Surgical Inflammation: From Molecule to Clinic

Pp. 18-50 (33)

Jose-Ignacio Arias, María-Angeles Aller, Gregorio Rodríguez-Boto, Manuel Giner and Jaime Arias

Abstract

Tetrapyrrole molecules are distributed in virtually all living organisms on Earth. In mammals, tetrapyrrole end products are closely linked to oxygen metabolism. Since increasingly complex trophic functional systems for using oxygen are considered in the post-traumatic inflammatory response, it can be suggested that tetrapyrrole molecules and, particularly their derived pigments, play a key role in modulating inflammation. In this way, the diverse colorfulness that the inflammatory response triggers during its evolution would reflect the major pathophysiological importance of these pigments in each one of its phases. Hence, the need of exploiting this color resource could be considered for both the diagnosis and treatment of the inflammation.

Keywords:

Post-traumatic inflammatory response, oxygen metabolism, tetrapyrroles, edema, necrosis, ischemia-reperfusion, hypoxia, cyanosis, ecchymosis, hemoglobin, pus, suppuration, scar.

Affiliation:

Cátedra de Cirugía, Facultad de Medicina, Universidad Complutense, Pza. de Ramón y Cajal s.n., 28040 MADRID, Spain.