The Role of the Heme Oxygenase System in the Metabolic Syndrome

Author(s): Ignazio Barbagallo, Anna Nicolosi, Giorgio Calabrese, Sabrina David, Sebastiano Cimino, Massimo Madonia, Francesco Cappello

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 31 , 2014

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Molecular chaperones and the heat shock response play a major role in the maintenance of cellular homeostasis under various pathological conditions. In particular, their role is to regulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellarnetworks. Among variousheat shock proteins, Hsp32 also known as heme oxygenase-1 (HO-1), has demonstrated an important role in metabolic syndrome. In particular, the HO system seems to play a major role in the complex pathophysiological cascade involved in insulin resistance mechanisms, and adipocyte functions as measured by the release of important adipokynes. The aim of the present review is to point out the role of HO-1 in metabolic syndrome, and how to exploit its beneficial effects as a therapeutic strategy to prevent complicationsof andto improve insulin sensitivity.

Keywords: Metabolic syndrome, heme oxygenase, insulin sensitivity, adiponectin, heat shock proteins.

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Article Details

Year: 2014
Published on: 05 December, 2013
Page: [4970 - 4974]
Pages: 5
DOI: 10.2174/1381612819666131206103824
Price: $65

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