Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased.
Most attention has focused on Δ9-tetrahydrocannabinol (Δ9-THC) as it is the psychoactive constituent of Cannabis sativa
(C. sativa). However, in previous years, the focus of interest in the second plant constituent with non-psychotropic
properties, cannabidiol (CBD) has been enhanced. Recently, several groups have investigated the pharmacological
properties of CBD with significant findings; furthermore, this compound has raised promising pharmacological properties
as a wake-inducing drug. In the current review, we will provide experimental evidence regarding the potential role of
CBD as a wake-inducing drug.