A 61-year-old white man presented with a stenosing tumour of the right colon and a large hepatic metastasis
measuring 90 mm in its largest diameter, judged not suitable for immediate resection. He underwent right hemicolectomy
and received 12 cycles of treatment with 5-fluorouracil/leucovorin, oxaliplatin and irinotecan (FOLFOXIRI) plus bevacizumab.
According to Response Evaluation Criteria in Solid Tumors (RECIST criteria), he achieved a partial response that
allowed a secondary radical hepatic resection. Pathologic examination of the liver specimen showed the absence of residual
tumour cells: a pathologic complete response (pCR) was achieved. In this case, an intensive up-front treatment (i.e. the
combination of FOLFOXIRI plus bevacizumab) produced the pCR of a liver metastasis from colorectal cancer despite its
initial large dimension while confirming the possible discrepancy between radiologic assessment and pathological findings.
Keywords: Metastatic colorectal cancer, liver resection, preoperative chemotherapy, bevacizumab, FOLFOXIRI, complete
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