Abstract
Combination of biomaterials with nanotechnology has been applied to the immobilization of chitosan on nano-gold particles by plasma and grafting treatments. In this study, gold (Au) nanoparticles were first synthesized by chemical reduction method using mixing solution of HAuCl44H2O and sodium citrate or NaBH4. The synthesized gold nanoparticles were then reacted with 11- mercaptoundecanoic acid (MUA) containing thiol group to modify the surface of gold nanoparticle. The MUA-modified Au nanoparticles were subjected to O2 plasma pretreatment before the UV light grafting polymerization with N-Isopropylacrylamide (NIPAAm) on the plasma-treated Au nanoparticles to form a thermosensitive polymer on the surface. The functional groups on the grafted Au nanoparticles surface were combined with glutaraldehyde to immobilize biological molecules of chitosan. The results show that preparation of nano-Au particles using NaBH4 solution as reductant is better than using the sodium citrate solution. The preferable reaction temperature for the preparation using NaBH4 solution to produce nano-Au particles is 100°C. From the TEM observation the prepared Au nanoparticle was spherical-like and about 10~20 nm in size. The zeta potential measurement on the immobilized Au nanoparticles proves that chitosan was indeed immobilized on the Au nanoparticles surface.
Keywords: Chitosan, gold, graft, NIPAAm, plasma, thermosensitive polymer.
Current Nanoscience
Title:Plasma Surface Treatment and Grafting of Nano-Gold Surface for Immobilization of Chitosan
Volume: 10 Issue: 2
Author(s): Hsin-Ming Wu, Yi-Syuan Wei, Ko-Shao Chen and Yi-Jang Liou
Affiliation:
Keywords: Chitosan, gold, graft, NIPAAm, plasma, thermosensitive polymer.
Abstract: Combination of biomaterials with nanotechnology has been applied to the immobilization of chitosan on nano-gold particles by plasma and grafting treatments. In this study, gold (Au) nanoparticles were first synthesized by chemical reduction method using mixing solution of HAuCl44H2O and sodium citrate or NaBH4. The synthesized gold nanoparticles were then reacted with 11- mercaptoundecanoic acid (MUA) containing thiol group to modify the surface of gold nanoparticle. The MUA-modified Au nanoparticles were subjected to O2 plasma pretreatment before the UV light grafting polymerization with N-Isopropylacrylamide (NIPAAm) on the plasma-treated Au nanoparticles to form a thermosensitive polymer on the surface. The functional groups on the grafted Au nanoparticles surface were combined with glutaraldehyde to immobilize biological molecules of chitosan. The results show that preparation of nano-Au particles using NaBH4 solution as reductant is better than using the sodium citrate solution. The preferable reaction temperature for the preparation using NaBH4 solution to produce nano-Au particles is 100°C. From the TEM observation the prepared Au nanoparticle was spherical-like and about 10~20 nm in size. The zeta potential measurement on the immobilized Au nanoparticles proves that chitosan was indeed immobilized on the Au nanoparticles surface.
Export Options
About this article
Cite this article as:
Wu Hsin-Ming, Wei Yi-Syuan, Chen Ko-Shao and Liou Yi-Jang, Plasma Surface Treatment and Grafting of Nano-Gold Surface for Immobilization of Chitosan, Current Nanoscience 2014; 10 (2) . https://dx.doi.org/10.2174/1573413709666131129000228
DOI https://dx.doi.org/10.2174/1573413709666131129000228 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Computer-Aided Drug Design of Bioactive Natural Products
Current Topics in Medicinal Chemistry Development and Validation of a High-Density Fluorescence Polarization-Based Assay for the Trypanosoma RNA Triphosphatase TbCet1
Combinatorial Chemistry & High Throughput Screening Qualitative and Quantitative Analysis of Phosphoproteomic Experimental Workflow Based on Phosphoprotein Enrichment Strategy and Two- Dimensional Difference Gel Electrophoresis (2D-DIGE) Techniques
Current Proteomics Identification of Disease States and Response to Therapy in Humans by Utilizing the Biomarker EGFR for Targeted Molecular Imaging
Current Protein & Peptide Science Bioaccessibility of Functional Ingredients
Current Nutrition & Food Science Exploring the Phosphoproteome with Mass Spectrometry
Mini-Reviews in Medicinal Chemistry Smoking and Hypertension: Independent or Additive Effects to Determining Vascular Damage?
Current Vascular Pharmacology WITHDRAWN: Current Trends in the Detection of Biological Proteins and Immunological Assays using Graphene Quantum Dots
Current Analytical Chemistry Electrochemical Modified Based Sensors: A New Approach for Analytical Chemistry
Current Analytical Chemistry Biotransformation of Silybin and its Congeners
Current Drug Metabolism Optical and Multimodal Peptide-Based Probes for In Vivo Molecular Imaging
Anti-Cancer Agents in Medicinal Chemistry Protein Kinase C – Possible Therapeutic Target to Treat Cardiovascular Diseases
Cardiovascular & Hematological Disorders-Drug Targets Small Molecules Modulating AHL-based Quorum Sensing to Attenuate Bacteria Virulence and Biofilms as Promising Antimicrobial Drugs
Current Medicinal Chemistry Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus
Current Pharmaceutical Design Microwave-promoted One-pot Synthesis of Imidazo[1,2-a]pyridines in Lemon Juice
Current Microwave Chemistry What Can Neuroscience Tell Us About the Potential of Psychedelics in Healthcare? How the Neurophenomenology of Psychedelics Research Could Help us to Flourish Throughout Our Lives, as Well as to Enhance Our Dying
Current Drug Abuse Reviews Phenothiazine: The Parent Molecule
Current Drug Targets The Application of Proteomics in Neurology
Current Proteomics Design, Synthesis, Molecular Docking, and Anticancer Evaluation of Pyrazole Linked Pyrazoline Derivatives with Carbothioamide Tail as EGFR Kinase Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Mitochondrial Respiratory Complex I: Structure, Function and Implication in Human Diseases
Current Medicinal Chemistry