To catalyze research on historically untargeted protein kinases, we created the PKIS, an annotated set of 367
small molecule kinase inhibitors. The set has been widely distributed to academic collaborators as an open access tool. It
has been used to identify chemical starting points for development of chemical probes for orphan kinases and to investigate
kinase signaling in high content phenotypic assays. Access to the set comes with few restrictions other than the requirement
that assay results be released into the public domain for the benefit of the entire research community. Examples
from the efforts of several collaborators are summarized.