NUCB2 and its proteolytically cleaved product nesfatin-1 were initially identified as hypothalamic neuroproteins that inhibit
food intake, via a leptin-independent pathway. Since then recent studies have found NUCB2/nesfatin-1 to be expressed both centrally, as
well as in peripheral tissues. The recent implementation of novel experimental approaches has produced a large body of evidence implicating
NUCB2/nesfatin-1 in a diverse range of biological functions and in the modulation of food intake, energy homeostasis and metabolism.
In this review, we discuss the discovery of NUCB2 and its proteolytic product nesfatin-1, and its expression in both central and
peripheral tissues. In addition we shed light on the most recent discoveries supporting the role for NUCB2/nesfatin-1 in peripheral tissues
and its association with metabolic alterations. Moreover, we highlight the importance of NUCB2 and nesfatin-1 in adipose tissue, its
regulation of adipogenesis and obesity-associated metabolic diseases.
Keywords: NUCB2, nesfatin-1, obesity, preadipocytes, adipocytes, white adipose tissue, brown adipose tissue and adipogenesis.
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