Title:Possible Role of NUCB2/nesfatin-1 in Adipogenesis
VOLUME: 19 ISSUE: 39
Author(s):Manjunath Ramanjaneya, Melisande Addison and Harpal S. Randeva
Affiliation:Division of Metabolic & Vascular Health, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Keywords:NUCB2, nesfatin-1, obesity, preadipocytes, adipocytes, white adipose tissue, brown adipose tissue and adipogenesis.
Abstract:NUCB2 and its proteolytically cleaved product nesfatin-1 were initially identified as hypothalamic neuroproteins that inhibit
food intake, via a leptin-independent pathway. Since then recent studies have found NUCB2/nesfatin-1 to be expressed both centrally, as
well as in peripheral tissues. The recent implementation of novel experimental approaches has produced a large body of evidence implicating
NUCB2/nesfatin-1 in a diverse range of biological functions and in the modulation of food intake, energy homeostasis and metabolism.
In this review, we discuss the discovery of NUCB2 and its proteolytic product nesfatin-1, and its expression in both central and
peripheral tissues. In addition we shed light on the most recent discoveries supporting the role for NUCB2/nesfatin-1 in peripheral tissues
and its association with metabolic alterations. Moreover, we highlight the importance of NUCB2 and nesfatin-1 in adipose tissue, its
regulation of adipogenesis and obesity-associated metabolic diseases.
