Sudden cardiac death (SCD) from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular
mortality. It has a multifactorial, complex nature and aggregates in families, implicating the involvement of heritable factors in
the determination of risk. During the last few years, genome-wide association studies have uncovered common genetic variants modulating
risk of SCD. We here review the current insight on genetic determinants of SCD in the community and describe the genome-wide association
approaches undertaken thus far in uncovering genetic determinants of SCD risk.