Abstract
Fatty acids have an important role in providing energy for sustained contractile activity and viability of the heart. However, considerable evidence now supports a role for fatty acids in the modulation of cardiovascular pathology as well. This may be beneficial or detrimental due to the structural differences in the various fatty acids. Polyunsaturated fatty acids appear to provide important protection to the heart during ischemic reperfusion challenge. Conversely, trans fatty acids are thought to mediate detrimental cardiac effects. Potentially pathological features of ischemic cardiomyocytes may be manifested as qualitative findings in studies of myocardial infarction and atherosclerosis. These general conclusions, however, are complicated by opposing effects that different fatty acids have even within the same group (i.e. n-6 versus n-3 fatty acids within the polyunsaturated fatty acids group, and industrial versus ruminant trans fats). Understanding more about how these fatty acid species alter ischemic myocardial injury is an increasingly attractive area of research. The identification of further targets of fatty acid interactions has great potential to provide valuable information for the modulation of cardiovascular disease.
Keywords: Ischemia, fatty acid, apoptosis, heart disease; reperfusion; atherosclerosis; trans fat, omega-3 fatty acid, polyunsaturated fatty acid.
Current Pharmaceutical Design
Title:Differential Effects of Trans and Polyunsaturated Fatty Acids on Ischemia/ Reperfusion Injury and its Associated Cardiovascular Disease States
Volume: 19 Issue: 39
Author(s): Riya Ganguly, Matthew S. Lytwyn and Grant N. Pierce
Affiliation:
Keywords: Ischemia, fatty acid, apoptosis, heart disease; reperfusion; atherosclerosis; trans fat, omega-3 fatty acid, polyunsaturated fatty acid.
Abstract: Fatty acids have an important role in providing energy for sustained contractile activity and viability of the heart. However, considerable evidence now supports a role for fatty acids in the modulation of cardiovascular pathology as well. This may be beneficial or detrimental due to the structural differences in the various fatty acids. Polyunsaturated fatty acids appear to provide important protection to the heart during ischemic reperfusion challenge. Conversely, trans fatty acids are thought to mediate detrimental cardiac effects. Potentially pathological features of ischemic cardiomyocytes may be manifested as qualitative findings in studies of myocardial infarction and atherosclerosis. These general conclusions, however, are complicated by opposing effects that different fatty acids have even within the same group (i.e. n-6 versus n-3 fatty acids within the polyunsaturated fatty acids group, and industrial versus ruminant trans fats). Understanding more about how these fatty acid species alter ischemic myocardial injury is an increasingly attractive area of research. The identification of further targets of fatty acid interactions has great potential to provide valuable information for the modulation of cardiovascular disease.
Export Options
About this article
Cite this article as:
Ganguly Riya, Lytwyn S. Matthew and Pierce N. Grant, Differential Effects of Trans and Polyunsaturated Fatty Acids on Ischemia/ Reperfusion Injury and its Associated Cardiovascular Disease States, Current Pharmaceutical Design 2013; 19 (39) . https://dx.doi.org/10.2174/138161281939131127111018
DOI https://dx.doi.org/10.2174/138161281939131127111018 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mechanisms of Action of Hypertonic Saline Resuscitation in Severe Sepsis and Septic Shock
Endocrine, Metabolic & Immune Disorders - Drug Targets Mechanical Support in Cardiogenic Shock Complicating Acute Coronary Syndrome: Ready for Prime Time?
Current Vascular Pharmacology Role of the Peroxynitrite - Poly (ADP-Ribose) Polymerase Pathway in the Pathogenesis of Liver Injury
Current Pharmaceutical Design The Antioxidants and Pro-Antioxidants Network: An Overview
Current Pharmaceutical Design IL-17A and Multiple Sclerosis: Signaling Pathways, Producing Cells and Target Cells in the Central Nervous System
Current Drug Targets Effectiveness of Resveratrol Against Cardiovascular Disease
Mini-Reviews in Organic Chemistry Update on Fondaparinux: Role in Management of Thromboembolic and Acute Coronary Events
Cardiovascular & Hematological Agents in Medicinal Chemistry Minocycline Repurposing in Critical Illness: Focus on Stroke
Current Topics in Medicinal Chemistry Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants
Mini-Reviews in Medicinal Chemistry Thioredoxin System Modulation by Plant and Fungal Secondary Metabolites
Current Medicinal Chemistry Induced Adaptive Resistance to Oxidative Stress in the CNS: A Discussion on Possible Mechanisms and Their Therapeutic Potential
Current Drug Metabolism Curcumin Attenuates Cerebral Ischemia-reperfusion Injury Through Regulating Mitophagy and Preserving Mitochondrial Function
Current Neurovascular Research Modulation of Staurosporine-Activated Volume-Sensitive Outwardly Rectifying Cl- Channel by PI3K/Akt in Cardiomyocytes
Current Pharmaceutical Design Stem Cells in Cardiovascular Regeneration: From Preservation of Endogenous Repair to Future Cardiovascular Therapies
Current Pharmaceutical Design Intravenous Implanted Neural Stem Cells Migrate to Injury Site, Reduce Infarct Volume, and Improve Behavior after Cerebral Ischemia
Current Neurovascular Research Anti-inflammatory Effects of Mesenchymal Stem Cells and their Secretomes in Pneumonia
Current Pharmaceutical Biotechnology Protective Effects and Mechanisms of Action of Ulinastatin against Cerebral Ischemia-Reperfusion Injury
Current Pharmaceutical Design Tyrosine Kinase Inhibitor as a new Therapy for Ischemic Stroke and other Neurologic Diseases: is there any Hope for a Better Outcome?
Current Neuropharmacology A Comprehensive Review of the Genus Pyrola Herbs in Traditional Uses, Phytochemistry and Pharmacological Activities
Current Topics in Medicinal Chemistry Biosynthesis and Biological Activities of In Vitro Derived Solasodine Glycoalkaloids from <i>Solanum laciniatum</i>
The Natural Products Journal