Benzothiazoles are promising candidates for the design of novel antiepileptic drugs. The endocyclic sulphur
and nitrogen functions present in this heterocyclic nucleus have been shown to be critical for the anticonvulsant activity.
The present review outlines the rational design and anticonvulsant potential of promising benzothiazole lead molecules.
Particular focus has been placed on the structure activity relationship of different benzothiazole derivatives giving selected
examples of molecules with significant activity being that these molecules may serve as prototypes for the development of
more active antiepileptic drugs.
Keywords: Anticonvulsant activity, benzothiazole, pharmacophore, SAR.
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