Helminths that are the causative agents of numerous neglected tropical diseases continue to be a major problem
for human global health. In the absence of vaccines, control relies solely on pharmacoprophylaxis and pharmacotherapy to
reduce transmission and to relieve symptoms. There are only a few drugs available and resistance in helminths of lifestock
has been observed to the same drugs that are also used to treat humans. Clearly there is an urgent need to find novel antiparasitic
compounds. Not only are helminths confronted with their own metabolically derived toxic and redox-active byproducts
but also with the production of reactive oxygen species (ROS) by the host immune system, adding to the overall
oxidative burden of the parasite. Antioxidant enzymes of helminths have been identified as essential proteins, some of
them biochemically distinct to their host counterpart and thus appealing drug targets. In this review we have selected a
few enzymatic antioxidants of helminths that are thought to be druggable.
Keywords: Anthelmintics, antioxidant, glutathione, helminths, nematode, oxidative stress, parasite, reactive oxygen species.
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