Title:Synthesis, Characterization and Antitumor Activity of Novel Triazole/ Isoxazole Tagged Pyridine Hybrids
VOLUME: 11 ISSUE: 4
Author(s):Raju K, Chandra Shekhar A, Sathaiah G, Ravi Kumar A, Narsaiah B, Shanthan Rao P, Srujana R and Srigiridhar Kotamraju
Affiliation:Fluoroorganic division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500607, India.
Keywords:Nicotinonitrile, propargylation, antitumor activity, 1, 2, 3-triazole, isoxazole.
Abstract:A series of novel 2-((1-substituted-1H-1,2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methoxy) substituted pyridine,
1-((1-substituted-1H-1,2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methyl)substituted pyridin-2(1H)-one was prepared
from 2-oxo-6-phenyl/methyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 3 via propargylation followed by 1,3-
dipolar cycloaddition of the propargyl derivatives 4 and 5. These triazole/isoxazole tagged pyridine derivatives were
evaluated for antitumor activity against breast cancer cell lines such as MDA-MB-231, MCF-7 etc. The results indicated
that compounds 6e, 6f, 8e and 8f were found to be active on MDA-MB-231, while 6h and 8h were active on MCF-7.
