Liquid-Phase Combinatorial Library Synthesis: Recent Advances and Future Perspectives

Author(s): Kuldipsinh P. Barot, Stoyanka Nikolova, Illiyan Ivanov, Manjunath D. Ghate

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 17 , Issue 5 , 2014

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Abstract:

Liquid-phase combinatorial library synthesis is commonly developed into the viable alternatives or adjunct across the broad spectrum of polymer-supported organic chemistry. It includes the use of soluble polymer supports in the combinatorial synthesis of peptides and small-molecular library compounds which act as catalyst and reagent supports. It also includes high throughput biological screening with generation and evaluation of chemical leads for drug discovery development. In this review, liquid-phase combinatorial library synthesis is shown as the most efficient method of choice for the synthesis of most of the combinatorial library compounds with specific approaches from different groups that state potentials of solution-phase combinatorial synthesis.

Keywords: Development, general techniques, library formation, multi-step synthesis, recent advances.

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Article Details

VOLUME: 17
ISSUE: 5
Year: 2014
Published on: 17 June, 2014
Page: [417 - 438]
Pages: 22
DOI: 10.2174/1386207316666131117172549
Price: $65

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