The bacterial biofilms and the emergence of multiple drug resistance have become a major threat for current
medical treatment of nosocomial infections. It has been estimated that about 65-80% of microbial infections in the developed
countries are associated with biofilms. Given the prominence of biofilms in infectious diseases, increasing efforts
toward the development of small molecules that will modulate bacterial biofilm development and maintenance is on the
rise. Till date, marine natural products have shown a tremendous potential as pharma leads and also given new skeletons
which would be used as biofilm/QS inhibitors. Medically relevant biofilm forming bacteria such as Pseudomonas aeruginosa
which is most frequently isolated bacteria in nosocomial infection is believed to be a model organism for biofilm
studies. Hence, in this review, we have highlighted the development of small molecules that inhibit and/or disperse bacterial
biofilms of P. aeruginosa in particular. Additionally, the rational design approaches as well as synthetic methodologies
along with biological studies has been accounted in this article.
Keywords: Marine natural products, biofilms, quorum sensing inhibitors, antifouling, chemical signaling.
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