Quantum Dot-Based Nanoprobes for In Vivo Targeted Imaging

Author(s): Y. Zhu, H. Hong, Z. P. Xu, Z. Li, W. Cai

Journal Name: Current Molecular Medicine

Volume 13 , Issue 10 , 2013

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Abstract:

Fluorescent semiconductor quantum dots (QDs) have attracted tremendous attention over the last decade. The superior optical properties of QDs over conventional organic dyes make them attractive labels for a wide variety of biomedical applications, whereas their potential toxicity and instability in biological environment have puzzled scientific researchers. Much research effort has been devoted to surface modification and functionalization of QDs to make them versatile probes for biomedical applications, and significant progress has been made over the last several years. This review article aims to describe the current state-of-the-art of the synthesis, modification, bioconjugation, and applications of QDs for in vivo targeted imaging. In addition, QD-based multifunctional nanoprobes are also summarized.

Keywords: Cancer nanotechnology, molecular imaging, multimodality imaging, nanoparticles (NPs), near-infrared fluorescence (NIRF), quantum dots (QDs).

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Article Details

VOLUME: 13
ISSUE: 10
Year: 2013
Page: [1549 - 1567]
Pages: 19
DOI: 10.2174/1566524013666131111121733
Price: $65

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