From 2005 to 2012, 236 new substances have been officially notified in European Union via the Early Warning
System with an increasing trend from year by year. In October 2009, 4-methylamphetamine (4-MA), an amphetamine
derivative, was detected in Belgium and on 14 December 2009 this stimulant was notified to the European Monitoring
Centre for Drugs and Drug Addiction. Since its appearance within the recreational drug market, some cases of severe
intoxication and deaths have been signaled across Europe. In this paper we summarized the chemical, pharmacological
and toxicological information about this new potential recreational drug.