Title:Solid Lipid Nanoparticles: An Innovative Nano-Vehicles for Drug Delivery
VOLUME: 4 ISSUE: 1
Author(s):Hema Chaudhary, Samita, Nitika Puri and Vikash Kumar
Affiliation:PDM College of Pharmacy, Bahadurgarh, Haryana, India.
Keywords:Nanotechnology, solid lipid nanoparticles (SLN), drug delivery, toxicity.
Abstract:Nanotechnology is an emergent field with numerous applications in drug delivery, clinical medicine,
nutriceuticals as well as in other fields also. In this techno, Solid lipid nanoparticles (SLN) is a part which consist solid
colloidal particles ranging in size from 1 to 1000 nm and act as “magic bullet” when coupled with ligands/targeting
ligands. SLN consisting of a solid-lipid promising advance delivery of lipophilic drugs and also used as an alternate for
conventional carriers such as micro-emulsions, liposomes and nanoparticles based on natural/synthetic polymers. They are
formulated from synthetic/natural lipids and optimize the drug delivery to provide a protection to sensitive drugs and
obtain better/improve bioavailability with less toxicity (as compared to polymeric NPs) due to its biodegradable/bioacceptable
nature. Moreover, Surface Modified SLNs is a new promising approach for protein loading and antigen
delivery system.
