Title:Organocatalyzed Green Synthesis of 2,3-dihydropyrazines en Route to Medicinally Privileged Novel Polyheterocyclic Systems
VOLUME: 1 ISSUE: 1
Author(s):Debasish Bandyopadhyay, Artemio Zavala and Bimal K. Banik
Affiliation:Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, Texas 78539, USA.
Keywords:Aqueous, anticancer, azaheterocycles, condensation, (±)-Camphor-10-sulfonic acid, 1, 2-Diamine, α, β-Dicarbonyl,
dihydropyrazine, ecofriendly synthesis, heterocycles, green chemistry, organocatalyst, polyheterocyclic compounds, pyrazine,
nitrogen heterocycles.
Abstract:A straightforward green synthesis of 2,3-dihydropyrazines was accomplished under the catalytic influence of
(±)-Camphor-10-sulfonic acid at room temperature by condensation of aliphatic 1,2-diamines with α,β-dicarbonyl compounds
in aqueous medium. Remarkable aspects of this newly reported method are high yields, use of non-toxic solvents,
mild conditions, simple workup and synthesis of complex molecules using an ecofriendly inexpensive organocatalyst. The
present method is atom-economical, environmentally benign, and affords synthetically useful and challenging products
very rapidly.
