Epithelial-mesenchymal transition (EMT) is a vital process implemented in embryo development, organ
fibrosis, and cancer metastasis. Several transcription factors and signaling pathways impinge on the transcriptional
program of the cell, leading to the change of cell phenotype without alteration of genotype. Accumulating evidence
suggests that epigenetic mechanisms play important roles in inducing EMT and orchestrating the heredity and reversibility
of EMT. In this review, we discuss how DNA methylation, histone modifications, and microRNAs (miRNAs) act in a
concerted manner to regulate EMT. ‘Epigenetic therapies’—inhibitors of DNA methyltransferases and histone
deacetylases as well as microRNAs are emerging as promising agents for cancer intervention.
Keywords: DNMT inhibitors, EMT, epigenetic regulation, epigenetic therapy, HDAC inhibitors, metastasis, miRNAs.
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Published on: 12 December, 2013
Page: [973 - 985]