O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions

Title:O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions

Volume: 11 Issue: 1

Author(s): Erika Bálint, Mónika Kállai, Orsolya Kovács, Hedvig Bölcskei and György Keglevich

Affiliation:

Keywords: 2-Flourobenzaldehyde, Iodophenols, Arylation, Microwave, Phase transfer catalysis.

Abstract: The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K₂CO₃ in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.

Cite this article as:

Bálint Erika, Kállai Mónika, Kovács Orsolya, Bölcskei Hedvig and Keglevich György, O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions, Letters in Drug Design & Discovery 2014; 11 (1) . https://dx.doi.org/10.2174/15701808113106660096