The purpose of this systematic review is to investigate on the relationship between synovial level of cytokines
and matrix metallo-proteinases and temporo-mandibular joint (TMJ) internal derangements (IDs) and/or osteoarthritis
(OA). Twelve studies were included in the review and markers were evaluated in respect to IDs and OA. Findings from
these investigations highlighted that higher levels of IL1β, IL-6, IL-11, TGFβ1 were associated to TMJ’s OA; on the other
hand, higher levels of MMP-2 and MMP-9 could correlate to ID without reduction (IDw/oR). Furthermore, higher levels
of MMP-9 could associate also to severe condition of TMJ’s OA. The findings of this systematic review could represent a
useful tool for diagnosis and prognosis of TMJ’s diseases, particularly about the effectiveness of arthroscopy and/or
arthrocentesis in patients submitted to repeated surgical treatments. The paper also outlines some recent patents.