Abstract
Numerous epidemiological studies indicate that consumption of polyphenol-rich food and beverages is associated with a protective effect on the cardiovascular system. The beneficial effect has been attributable to several mechanisms including the improvement of the vascular function. Indeed, polyphenols have been shown to be potent stimulators of endothelial vasoprotective mechanisms including the formation of nitric oxide (NO) and the induction of endothelium-derived hyperpolarization (EDH). The aim of this review is to provide a non-exhaustive analysis of the literature regarding polyphenols-rich sources capable of activating endothelial NO synthase and the characterization of the underlying mechanism as well as the beneficial effects of polyphenols on the endothelial function in both experimental models of cardiovascular diseases and in Humans.
Keywords: Endothelial NO synthase, polyphenol, red wine, nitric oxide, endothelial function.
Current Pharmaceutical Design
Title:Activation of eNOS by Polyphenol-rich Products and Polyphenolic Compounds
Volume: 20 Issue: 22
Author(s): Jong Hun Kim, Cyril Auger and Valerie B. Schini-Kerth
Affiliation:
Keywords: Endothelial NO synthase, polyphenol, red wine, nitric oxide, endothelial function.
Abstract: Numerous epidemiological studies indicate that consumption of polyphenol-rich food and beverages is associated with a protective effect on the cardiovascular system. The beneficial effect has been attributable to several mechanisms including the improvement of the vascular function. Indeed, polyphenols have been shown to be potent stimulators of endothelial vasoprotective mechanisms including the formation of nitric oxide (NO) and the induction of endothelium-derived hyperpolarization (EDH). The aim of this review is to provide a non-exhaustive analysis of the literature regarding polyphenols-rich sources capable of activating endothelial NO synthase and the characterization of the underlying mechanism as well as the beneficial effects of polyphenols on the endothelial function in both experimental models of cardiovascular diseases and in Humans.
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Cite this article as:
Kim Hun Jong, Auger Cyril and Schini-Kerth B. Valerie, Activation of eNOS by Polyphenol-rich Products and Polyphenolic Compounds, Current Pharmaceutical Design 2014; 20 (22) . https://dx.doi.org/10.2174/13816128113196660751
DOI https://dx.doi.org/10.2174/13816128113196660751 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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