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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]- 2,8'-Diones Using a One-Pot Reaction

Author(s): Abbas Rahmati, Zahra Khalesi and Tahmineh Kenarkoohi

Volume 17, Issue 2, 2014

Page: [132 - 140] Pages: 9

DOI: 10.2174/13862073113166660067

Price: $65

Abstract

A one-pot, three-component reaction of an isatin and kojic acid with an active methylene compound such as ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'- amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'-diones in good to excellent yields under reflux conditions, is described.

Keywords: Isatin, kojic acid, malononitrile, multi-component reaction, pyrano[3, 2-b]pyranone, pyranopyranone.


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