This review summarizes the effects of resveratrol in neurodegenerative diseases and speculates on the direction the field will
take in the immediate future. In particular, we emphasize studies on the effects of resveratrol on new pathways related to neurodegenerative
diseases such as inflammatory processes, mitochondrial biogenesis and its control through gamma coactivator 1- (PGC1), and the
role of the tandem sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) in neurodegeneration and in neurohormesis. While not
all reported results are free from controversy, the demographic shift toward an older population makes compounds with this broad spectrum
of potential clinical applications particularly interesting.
Keywords: Resveratrol, polyphenols, sirtuin 1, aging, neurodegeneration, inflammation, autophagy
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