Synthesis and Antitumor Invasive Activity of Novel Ionone Alkaloid Derivatives

Title:Synthesis and Antitumor Invasive Activity of Novel Ionone Alkaloid Derivatives

VOLUME: 11 ISSUE: 4

Author(s):Hai-Jun Fang, Qian Liu, Chun-Chun Gan, Mei-Na Jin, Nan Qin and Hong-Quan Duan

Affiliation:Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, People's Republic of China.

Keywords:Antitumor metastasis, Breast cancer cells, Derivative synthesis, Invasion assay, Ionone alkaloid, (E)-4-(3-[(4- fluorobenzyl)(methyl)amino]but-1-en-1-yl)-3, 5, 5-trimethylcyclohex-2-en-1-one.

Abstract:Two series of new ionone alkaloid derivatives were synthesized and evaluated for antitumor invasive activities in human MDA-MB-231 breast cancer cells. The structures of derivatives were elucidated by ¹H, ¹³C NMR and mass spectrometric methods. Ionone alkaloid derivatives 1a, 1c, 1d, 4i, 4j and 4k revealed significant inhibitory effects on the invasion of MDA-MB-231 cells in invasion assay, and compound 4j bearing a 4-fluoro benzene group of ionone alkaloid exhibited potent anti-invasive activity with an IC₅₀ value of 0.054 µM.

Cite this article as:

Hai-Jun Fang, Qian Liu, Chun-Chun Gan, Mei-Na Jin, Nan Qin and Hong-Quan Duan, “Synthesis and Antitumor Invasive Activity of Novel Ionone Alkaloid Derivatives”, Letters in Drug Design & Discovery (2014) 11: 395. https://doi.org/10.2174/15701808113106660094

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