Selected Recent Advances in the Synthesis of Bioactive Compounds Using Olefin Metathesis as a Key Step

Author(s): Benjamin Dassonneville, Lionel Delaude, Albert Demonceau, Ileana Dragutan, Valerian Dragutan, Koffi Sénam Etsè, Morgan Hans

Journal Name: Current Organic Chemistry

Volume 17 , Issue 22 , 2013

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Synthesis of biologically active compounds is of paramount importance to the biomedical sciences for the development of novel therapeutic agents. Such substances often feature various types of unique and complex structures, which make them challenging targets for synthetic efforts. Their total synthesis offers the chance to implement the use of newly developed, efficient and highly selective synthetic procedures and/or strategies in a complex environment. In this respect, thanks to the development of increasingly efficient molybdenum and ruthenium catalysts, olefin metathesis is now an integral part of modern synthetic methods. This review article will highlight with selected examples from the recent literature assets and limitations of the olefin metathesis reaction in the synthesis of biologically active compounds.

Keywords: Cross-metathesis, Natural products, Olefin metathesis, Relay ring-closing metathesis, Ring-closing metathesis, Ruthenium catalysts, Tandem olefin metathesis, Temporary tethered olefin metathesis.

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Article Details

Year: 2013
Page: [2609 - 2653]
Pages: 45
DOI: 10.2174/1385272811317220006
Price: $58

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