In Vitro Antitumoral Activity of Palladium(II) and Platinum(II) Complexes with O,O'-Dialkyl Esters of Ethylene-bis(S)-Leucine

Author(s): Jelena M. Vujic, Goran N. Kaluderovic, Tatjana P. Stanojkovic, Jadranka A. Antic, Srecko R. Trifunovic

Journal Name: Letters in Drug Design & Discovery

Volume 11 , Issue 4 , 2014

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Graphical Abstract:


Cytotoxic activity of four O,O'-dialkyl esters of ethylene-bis(S)-leucine [(S,S)-ethylenediamine-N,N’-di-2-(4- methyl)pentanoic acid] dihydrochlorides, R2edda-type esters L1.2HCl–L4.2HCl (alkyl = Et, n-Pr, n-Bu, and n-Pe, respectively), and corresponding palladium(II) (1–4) and platinum(II) (5–8) complexes against MDA-MB-361, MDA-MB-453 (human breast cancer), Jurkat (T-leukemia) and K562 (chronic myelogenous leukaemia) cell lines were determined. Results indicate cytotoxic potential of the investigated complexes based on induction of apoptosis.

Keywords: Palladium(II) complexes, Platinum(II) complexes, EDDA-type ligands, Human breast cancer, T-leukemia, Chronic myelogenous leukaemia.

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Article Details

Year: 2014
Page: [387 - 394]
Pages: 8
DOI: 10.2174/15701808113106660092
Price: $65

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