Abstract
2-Aminoimidazole skeleton represents a unique building block which is often used in the design of modulators of different targets and small molecule drugs. Alkaloids isolated from marine sponges are known to be one of the most common sources of the 2-aminoimidazole compounds and from a medicinal chemistry perspective, the marine alkaloids' fascinating structures as well as their broad spectrum of pharmacological activity make them promising lead compounds for various druggable targets. This review will focus on the presentation of biologically evaluated 2-aminoimidazole compounds showing a variety of pharmacological properties and their structure-activity relationship. The importance of 2-aminoimidazoles as bioisosteres of guanidine, acylguanidine, benzamidine and triazole groups will be highlighted.
Keywords: 2-aminoimidazole, alkaloids, lead compounds, marine compounds, medicinal chemistry, scaffold, secondary metabolites.
Mini-Reviews in Medicinal Chemistry
Title:2-Aminoimidazoles in Medicinal Chemistry
Volume: 13 Issue: 13
Author(s): AleŠ Žula, Danijel Kikelj and Janez Ilaš
Affiliation:
Keywords: 2-aminoimidazole, alkaloids, lead compounds, marine compounds, medicinal chemistry, scaffold, secondary metabolites.
Abstract: 2-Aminoimidazole skeleton represents a unique building block which is often used in the design of modulators of different targets and small molecule drugs. Alkaloids isolated from marine sponges are known to be one of the most common sources of the 2-aminoimidazole compounds and from a medicinal chemistry perspective, the marine alkaloids' fascinating structures as well as their broad spectrum of pharmacological activity make them promising lead compounds for various druggable targets. This review will focus on the presentation of biologically evaluated 2-aminoimidazole compounds showing a variety of pharmacological properties and their structure-activity relationship. The importance of 2-aminoimidazoles as bioisosteres of guanidine, acylguanidine, benzamidine and triazole groups will be highlighted.
Export Options
About this article
Cite this article as:
Žula AleŠ, Kikelj Danijel and Ilaš Janez, 2-Aminoimidazoles in Medicinal Chemistry, Mini-Reviews in Medicinal Chemistry 2013; 13 (13) . https://dx.doi.org/10.2174/1389557511313130007
DOI https://dx.doi.org/10.2174/1389557511313130007 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
DNA Vaccines: A Mini Review
Recent Patents on DNA & Gene Sequences Involvement of PI3K, Akt and RhoA in Oestradiol Regulation of Cardiac iNOS Expression
Current Vascular Pharmacology MICA Gene and Relevance to Immune Responses in Organ Transplants and Inflammatory, Tumoral and Autoimmune Diseases
Current Immunology Reviews (Discontinued) Can Diabetes Heal?- From Observations to Perspectives
Current Diabetes Reviews Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain
Endocrine, Metabolic & Immune Disorders - Drug Targets Improvement of Livestock Breeding Strategies Using Physiologic and Functional Genomic Information of the Muscle Regulatory Factors Gene Family for Skeletal Muscle Development
Current Genomics HMGB1-Directed Drug Discovery Targeting Cutaneous Inflammatory Dysregulation
Current Drug Metabolism Novel Drugs for Diabetes Also Have Dramatic Benefits on Hard Outcomes of Heart and Kidney Disease
Current Cardiology Reviews Drug Hypersensitivity: Epidemiology and Risk Factors
Current Pharmaceutical Design Toward Greater Insights on Applications of Modeling and Simulation in Pregnancy
Current Drug Metabolism Effects of Resveratrol and ACE Inhibitor Enalapril on Glucose and Lipid Profiles in Mice
Protein & Peptide Letters Stem Cells: A Golden Therapy for Diabetic Wounds
Current Diabetes Reviews Astatine Radiopharmaceuticals: Prospects and Problems
Current Radiopharmaceuticals Potential Therapeutic Targets in Energy Metabolism Pathways of Breast Cancer
Current Cancer Drug Targets Targeting the SH2 Domain-Containing Inositol Phosphatase (SHIP) for Therapy
Current Enzyme Inhibition Dietary Assumption of Plant Polyphenols and Prevention of Allergy
Current Pharmaceutical Design Pancreastatin, A Regulatory Peptide that Modulates Energy Metabolism
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Synthesis, Docking and Evaluation of Phenylacetic Acid and Trifluoro-methylphenyl Substituted Benzamide Derivatives as Potential PPARδ Agonists
Letters in Drug Design & Discovery Energetic Metabolic Roles in Pulmonary Arterial Hypertension and Right Ventricular Remodeling
Current Pharmaceutical Design Therapeutic Agents for COVID-19: an Overview
Current Drug Therapy