Abstract
DNA replication is the basis for biological inheritance, involving a series of sophisticated biochemical processes. Over the past decades, numerous in vitro or in vivo experiments have been implemented among a variety of organisms. While these resource-intensive techniques may always be costly, time-consuming or unable to measure the replication process on a global scale. Recently, mathematical modeling and computational simulation of biochemical processes that can be used for rapid testing of biology hypotheses have attracted considerable attention. In this review, we outline some key mathematical and computational works proposed recently for DNA replication process, with emphasis on the modeling and simulation of the replication origin identification and characterization, the replication process initiation and regulation, and the genome-wide profiling of DNA replication. Although many excellent works have been done, for a deeper insight into the DNA replication process, further iteration of mathematical modeling and biochemical experiment are still needed, and the prospective and possible research directions are discussed herein.
Keywords: Computational simulation, DNA replication, mathematical modeling, replication initiation, replication origin identification, replication regulation.
Current Bioinformatics
Title:Recent Advances in Mathematical Modeling and Simulation of DNA Replication Process.
Volume: 8 Issue: 5
Author(s): Guoli Ji, Yong Zeng, Jinting Guan, Qingshun Q. Li, Congting Ye and Yunlong Liu
Affiliation:
Keywords: Computational simulation, DNA replication, mathematical modeling, replication initiation, replication origin identification, replication regulation.
Abstract: DNA replication is the basis for biological inheritance, involving a series of sophisticated biochemical processes. Over the past decades, numerous in vitro or in vivo experiments have been implemented among a variety of organisms. While these resource-intensive techniques may always be costly, time-consuming or unable to measure the replication process on a global scale. Recently, mathematical modeling and computational simulation of biochemical processes that can be used for rapid testing of biology hypotheses have attracted considerable attention. In this review, we outline some key mathematical and computational works proposed recently for DNA replication process, with emphasis on the modeling and simulation of the replication origin identification and characterization, the replication process initiation and regulation, and the genome-wide profiling of DNA replication. Although many excellent works have been done, for a deeper insight into the DNA replication process, further iteration of mathematical modeling and biochemical experiment are still needed, and the prospective and possible research directions are discussed herein.
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Cite this article as:
Ji Guoli, Zeng Yong, Guan Jinting, Li Q. Qingshun, Ye Congting and Liu Yunlong, Recent Advances in Mathematical Modeling and Simulation of DNA Replication Process., Current Bioinformatics 2013; 8 (5) . https://dx.doi.org/10.2174/15748936113088880005
DOI https://dx.doi.org/10.2174/15748936113088880005 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
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