With the convergence of modern technology in genomics, proteomics, carbohydrate, protein and lipid biochemistry
as well as decades of experience in vaccine development and delivery of immunization programs, the Global Vaccine
Action Plan has declared 2011 to 2020 as ‘The Decade of Vaccines’. This review focuses on bacterial vaccines and summarises
the current state of vaccinology in bacteriology and looks forward to the potential of how the newer technologies
can impact our knowledge of bacterial diseases and their control through vaccine development. The major breakthroughs
in the last couple of decades include low cost high throughput genomics, proteomics, cellular immunology and the delicate
network of immune-cytokines, bioinformatics, immune-informatics, and disease modelling. Together, these newer
developments can provide a real impact on our understanding of infectious diseases and their control by vaccination.