Tuning the Activity of Antioxidants from a Chemical Point of View

Author(s): Waled Tantawy

Journal Name: Mini-Reviews in Organic Chemistry

Volume 11 , Issue 2 , 2014

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The current work discussed the criteria that control the non-enzymatic and enzymatic antioxidant activity from a chemical point of view. Two tunable strategies were classified to emphasize the reactivity of non-enzymatic one from the thermodynamic and kinetic perspectives. On the other hand, the non-covalent interactions and the intermediacy of reactive compounds formation were found to be the most efficient tools to modulate the activity of enzymatic antioxidant. Furthermore, the light has been shed on the pro-oxidant behavior of some antioxidants.

Keywords: 2c-3e interaction, antioxidant activity, GPx activity, -stacking, PCET, pro-oxidant activity, selenocompounds.

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Article Details

Year: 2014
Page: [186 - 224]
Pages: 39
DOI: 10.2174/1570193X113106660021
Price: $65

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