The current work discussed the criteria that control the non-enzymatic and enzymatic antioxidant activity from
a chemical point of view. Two tunable strategies were classified to emphasize the reactivity of non-enzymatic one from
the thermodynamic and kinetic perspectives. On the other hand, the non-covalent interactions and the intermediacy of reactive
compounds formation were found to be the most efficient tools to modulate the activity of enzymatic antioxidant.
Furthermore, the light has been shed on the pro-oxidant behavior of some antioxidants.
Keywords: 2c-3e interaction, antioxidant activity, GPx activity, -stacking, PCET, pro-oxidant activity, selenocompounds.
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